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Exercise and cold exposure induce PGC-1 coactivators, amplifying ERR-dependent gene sets involved in fatty-acid uptake and -oxidation (for example, CPT1, MCAD), OXPHOS subunits, TCA cycle enzymes, and mitochondrial transcription factors (for example, TFAM)

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This occurs because creatine increases the amount of phosphocreatine stored in your muscles, leading to more water being pulled (1) into those muscle cells